中性粒细胞/淋巴细胞比值等4项指标对溃疡性结肠炎内镜活动度的判断价值

目的 探讨中性粒细胞/淋巴细胞比值(neutrophils-lymphocytes ratio,NLR)、单核细胞/淋巴细胞比值(monocyte-lymphocytes ratio,MLR)、C 反应蛋白(C-reactive protein,CRP)、红细胞沉降率(erythrocyte sedimentation...

Value of NLR,MLR,CRP and ESR in judging the endoscopic activity of ulcerative colitis

Objective To explore the value of neutrophil/lymphocyte ratio(NLR),monocyte/lymphocytes ratio(MLR),Creactive protein(CRP),erythrocyte sedimentation rate(ESR)in judging the endoscopic activity of ulcerative colitis.Method Data were collected from 112 UC patients and 87 patients with irritable bowel syndrome(IBS)who were hospitalized in the First Affiliated Hospital of Guangxi Medical University from August 2012 to August 2018.The included patients were grouping basing on the modified Mayo score and Montreal classification.UC patients’endoscopy disease activity was judged by modified Mayo score.And researchers explored the value of NLR,MLR,CRP,ESR in judging the disease activity degree of UC endoscope.Results Frist,NLR,MLR,CRP,ESR in UC group were higher than that in IBS group.Second,The NLR,MLR,CRP and ESR in active period of the UC group were higher than that in healing period,and the levels of NLR,MLR,CRP and ESR were positively related to the modified Mayoscore under the endoscope.There was no statistically significant difference on NLR,MLR and CRP in different lesions.Third,the ROC curve of NLR,MLR,CRP,and ESR separately evaluating the UC endoscope activity separately suggested that the NLR had the best efficiency in evaluating the UC endoscope activity when separately exploring vaule of NLR,MLR,CRP and ESR(AUC 0.795,sensitivity 84.4%,specificity 68.7%).And the combined judgment of the four index was better than any singleindex.(AUC 0.850,sensitivity66.7%,specificity 93.7%).The four combined detection was better than the index alone in judging the UC endoscopic activity efficiency.Conclusion NLR,MLR,CRP and ESR reflect the UC endoscopy activety.Among them,NLR has the best performance.And the combined judgment of the four indexis better than any single index.