Associative recognition in mild cognitive impairment: Relationship to hippocampal volume and apolipoprotein E |
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Authors: | Angela K. Troyer Kelly J. Murphy Nicole D. Anderson Fergus I.M. Craik Morris Moscovitch Andrea Maione Fuqiang Gao |
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Affiliation: | 1. Neuropsychology and Cognitive Health Program, Baycrest, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1;2. Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, Canada M5S 3G3;3. Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1;4. Department of Medicine (Psychiatry), University of Toronto, 1 King’s College Circle, Toronto, ON, Canada M5S 1A8;5. LC Campbell Cognitive Neurology Research Unit, Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute & University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 |
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Abstract: | Associative memory involves remembering relations between items of information and is critically dependent on the hippocampus, a brain structure that shows early changes in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease. We examined associative and item memory in aMCI with a focus on the role of medial-temporal lobe regions and genetic risk for Alzheimer's disease. Twenty-four individuals with aMCI and 21 demographically matched healthy older adults underwent associative recognition testing, structural brain imaging, and apolipoprotein E (ApoE) genotyping. A significant interaction between group and recognition type indicated poorer associative recognition than item recognition across tasks in the aMCI group relative to controls. Within the aMCI group, associative but not item recognition showed sizable and significant correlations with hippocampal volume (but not with other medial temporal-lobe structures) and with number of ApoE ε4 alleles. Correlations were smaller and generally not significant in the control group. Our findings replicate and extend previous studies by showing an associative recognition impairment in aMCI that is not accounted for by an item recognition deficit, is related to structural integrity of the hippocampus, and increases with genetic risk for Alzheimer's disease. |
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