The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
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| Authors: | Guo Wen Wang Hui Chen Dan Wu Xiao-Qiong Tong Jian-Bin Li Chang-Qi Lei De-Liang Cai Wei-Jun Li Zhi-Yuan Luo Xue-Gang |
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| Affiliation: | 1.Department of Anatomy & Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China;2.Department of Physical Education, Hunan First Normal University, Changsha, Hunan 410012, China |
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| Abstract: | Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue. |
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| Keywords: | exercise central fatigue peripheral fatigue acetylcholinesterase neuromuscular junctions |
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