| 血吸虫病小鼠肝色素的沉积与吡喹酮治疗作用的关系 |
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| 引用本文： | 陶君,蔡卫民,张彬彬,黄(龙天),项泉,刘荣华. 血吸虫病小鼠肝色素的沉积与吡喹酮治疗作用的关系[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(1): 79-80 |
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| 作者姓名： | 陶君 蔡卫民 张彬彬 黄(龙天) 项泉 刘荣华 |
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| 作者单位： | 1. 中国人民解放军杭州疗养院检验科,杭州,310007
2. 浙江大学医学院附属第一医院传染病研究所,杭州,310003 |
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| 摘 要： | 色素是血吸虫摄入宿主红细胞后的代谢产物,宿主感染血吸虫后肝中色素沉积有一定规律性,首先沉积在肝窦内,然后分别在虫卵肉芽肿的外侧和内侧,最后沉积在虫卵周围,沉积的量与肝纤维化程度呈正比(P<0.01)。经吡喹酮治疗后色素沉积量明显减少、虫卵肉芽肿减小(P均<0.01)。根据肝细胞色素沉积特点及量的变化,可判断血吸虫病小鼠肝纤维化进程以及评判吡喹酮治疗效果。
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| 关 键 词： | 血吸虫病 肝纤维化 色素 |
| 文章编号： | 1000-7423（2006）-01-0079-02 |
| 收稿时间： | 2005-01-14 |
| 修稿时间： | 2005-01-14 |
Pigment Deposit in Liver of BALB/c Mice Infected by Schistosoma japonicum and its Relation to the Effect of Praziquantel Treatment |
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| TAO Jun,CAI Wei-min,Zhang Bin-bin,Huang Yan,Xiang Quan,LIU Rong-hua. Pigment Deposit in Liver of BALB/c Mice Infected by Schistosoma japonicum and its Relation to the Effect of Praziquantel Treatment[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2006, 24(1): 79-80 |
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| Authors: | TAO Jun CAI Wei-min Zhang Bin-bin Huang Yan Xiang Quan LIU Rong-hua |
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| Affiliation: | 1 Examination laboratory, Hangzhou Army Sanitarium, Hangzhou 310007, China; 2 Institute of Infectious Diseases, First Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Pigment is a kind of metabolite excreted by schistosome after erythrocyte ingestion. It deposited first in liver sinusoid, then outside and inside of granuloma, and around eggs. The level of pigment was in parallel with the degree of liver fibrosis(P<0^01). After chemotherapy with praziquantel, the level of pigment decreased considerably(P<0^01) and the size of granuloma shrinked obviously too(P<0^01). Therefore, the degree of liver fibrosis in mice with schistosome infection and the effect of praziquantel can be recognized by the level and distribution of pigment. |
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| Keywords: | Schistosoma japonicum Liver fibrosis Pigment |
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