| 环己基腺苷对大鼠脑损伤后神经功能的保护作用 |
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| 引用本文： | 童武松,卢亦成,江基尧,朱诚. 环己基腺苷对大鼠脑损伤后神经功能的保护作用[J]. 第二军医大学学报, 2002, 23(3): 287-289 |
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| 作者姓名： | 童武松 卢亦成 江基尧 朱诚 |
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| 作者单位： | 1. 解放军第411医院神经外科,上海,200081
2. 第二军医大学长征医院神经外科 |
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| 基金项目： | 全军“九五”医学科研规划指令性课题资助项目( 96L 0 36) . |
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| 摘 要： | 目的:探讨腺苷A1受体激动剂对大鼠液压脑损伤后神经功能和病理学改变的影响.方法:在大鼠液压脑损伤前10 min给予不同剂量的腺苷A1受体激动剂环己基腺苷(CHA),观察动物神经行为和病理学的改变.结果:与对照组相比,CHA能明显改善大鼠神经行为障碍和减轻脑组织的病理损害.结论:腺苷A1受体在大鼠液压脑损伤后起重要的神经保护作用.
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| 关 键 词： | 脑损伤、神经功能、环己基腺苷 |
| 文章编号： | 0258-879X(2002)03-0287-03 |
| 修稿时间： | 2001-08-21 |
Protective effects of N6-cyclohexyladenosine on neural function after brain trauma in rats |
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| TONG Wu Song ,LU Yi Cheng ,JIANG Ji Yao ,ZHU Cheng. Protective effects of N6-cyclohexyladenosine on neural function after brain trauma in rats[J]. Former Academic Journal of Second Military Medical University, 2002, 23(3): 287-289 |
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| Authors: | TONG Wu Song LU Yi Cheng JIANG Ji Yao ZHU Cheng |
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| Affiliation: | TONG Wu Song 1,LU Yi Cheng 2,JIANG Ji Yao 2,ZHU Cheng 2 |
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| Abstract: | Objective: To investigate the effects of adenosine A 1 receptor agonist N 6 cyclohexyladenosine(CHA) on neurofunction after fluid percussion injury in rats. Methods: The effects of CHA intra cerebroventricular injection 10 min before brain trauma on rats neurofunction and neuropathological changes were evaluated. Results: Compared with the control group, CHA could ameliorate the behavior deficits and improve pathological change. Conclusion: Adenosine A 1 receptor plays an important neuroprotective role in rat secondary injuries following brain trauma. |
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| Keywords: | brain injuries neural function N 6 cyclohexyladenosine |
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