Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients |
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| Authors: | ?uszczek Wioleta Kubicka Wioletta Cislo Maria Nockowski Piotr Mańczak Maria Woszczek Grzegorz Baran Eugeniusz Ku?nierczyk Piotr |
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| Institution: | Department of Clinical Immunology, Laboratory of Immunogenetics, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, PL-53-114, Wroclaw, Poland. |
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| Abstract: | Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls. We have found significantly higher representation of HLA-Cw*06 (odds ratio, 18.73; P(cor)<0.001) and significantly lower representation of HLA-Cw*07 (odds ratio, 0.41; P(cor)<0.038) in patients than in controls. Association of HLA-Cw*06 with psoriasis was even stronger in early age at onset (0-20 years) group: odds ratio, 77.71; P(cor)<0.001. Therefore, our population seems to belong to those with strong association of psoriasis with HLA-Cw*06. |
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