2004年20株细菌性痢疾菌谱及耐药性分析

目的 了解2004年来广东省细菌性痢疾的菌谱及耐药性。方法 分析20株痢疾杆菌的菌谱及对27种抗生素的耐药情况。结果 头孢他定、呋喃妥因的敏感率最高达100％，其次是多粘菌素、环丙沙星、诺氟沙星、庆大霉素、妥布霉素为95％，这些药在缓解临床症状细菌学转阴率有较好疗效。青霉素的耐药率高达100％，其次是利福平、磺胺甲基异嗯唑，这些药的耐药菌株的产生呈上升趋势。结论 近年来痢疾杆菌耐药菌株发生变迁，治疗应选用高效抗生素联合应用，并保证足够的疗程，以减少耐药现象。

Study on bacteria spectrum and drug resistance of 20 strains bacillus dysenteriae in 2004

Objective To study the bacteria spectrum and drug resistance of bacteria spectrum of Guangdong in 2004. Methods We analyzed the bacteria spectrum of 20 strains bacillus dysenteriae and the drug resistance to 27 kinds of antibacterial. Results The susceptible rates to ceftazidime,nitrofurantoin were 100%. The susceptible rates to polymyxinB, ciprrofloxacin, norfloxacin,gentamycin and tobramycin were 95%. These drugs in alleviating clinical symptom and the rates of turning to negative were effective. The resistant rates to Penicillin was 100%. The resistant rates to rifampin and sulfamethoxazole were increasing. Conclusion In recent years the resistant strains of bacillus dysenteriae are changing. It is necessary to use unitedly antibacterial efficient and ensure enough course of treatment to reduce the resistance.