| B细胞活化因子及其受体BR3在强直性脊柱炎患者外周血白细胞中的表达及临床意义初探 |
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| 引用本文： | 吴洪坤,张玲珍,周琳,仲人前.B细胞活化因子及其受体BR3在强直性脊柱炎患者外周血白细胞中的表达及临床意义初探[J].现代免疫学,2011(1):17-21. |
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| 作者姓名： | 吴洪坤 张玲珍 周琳 仲人前 |
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| 作者单位： | 第二军医大学附属长征医院实验诊断科全军临床免疫中心; |
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| 基金项目： | 国家自然科学基金资助项目(30901368); 上海市青年科技启明明星计划资助项目(09QA1407400) |
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| 摘 要： | 为了探讨强直性脊柱炎(AS)患者外周血白细胞中B细胞活化因子(BAFF)及其受体(BR3)的表达水平及其临床意义.采用流式细胞术检测24例AS患者、30名健康体检者外周血白细胞上BAFF、BR3的表达水平,并比较其与红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgG、IgA、IgM)的相关性.结果显示.A...
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| 关 键 词： | B细胞活化因子 受体 强直性脊柱炎 流式细胞术 |
Expression of B-cell activation factor and its receptor BR3 in peripheral blood leukocytes from patients with ankylosing spondylitis and its clinical significance |
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| WU Hong-kun,ZHANG Ling-zhen,ZHOU Lin,ZHONG Ren-qian.Expression of B-cell activation factor and its receptor BR3 in peripheral blood leukocytes from patients with ankylosing spondylitis and its clinical significance[J].Current Immunology,2011(1):17-21. |
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| Authors: | WU Hong-kun ZHANG Ling-zhen ZHOU Lin ZHONG Ren-qian |
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| Institution: | WU Hong-kun,ZHANG Ling-zhen,ZHOU Lin,ZHONG Ren-qian(Department of Laboratory Diagnosis,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China) |
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| Abstract: | To investigate the expression of B-cell activation factor(BAFF) and its receptor BR3 in the peripheral blood of patients with ankylosing spondylitis(AS),and to evaluate its clinical significance,the expression of BAFF and BR3 on the peripheral blood mononuclear cells were assayed with flow cytometry,and the correlation between their membrane-bound expression levels and the concentration of ESR,CRP,IgG,IgA and IgM was analyzed.The results showed that the expression of BAFF on peripheral blood monocytes of AS... |
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| Keywords: | B cell activating factor receptor ankylosing spondylitis flow cytometry |
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