| N-乙酰半胱氨酸抗X射线照射小鼠损伤效应 |
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| 引用本文： | 安治国,王欣,刘仲祥. N-乙酰半胱氨酸抗X射线照射小鼠损伤效应[J]. 癌变．畸变．突变, 2004, 16(4): 223-225. DOI: 10.3969/j.issn.1004-616x.2004.04.011 |
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| 作者姓名： | 安治国 王欣 刘仲祥 |
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| 作者单位： | 吉林大学白求恩医学部中日联谊医院，吉林 长春 130033 |
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| 摘 要： | 背景与目的：探讨N-乙酰左旋半胱氨酸(NAC)抗X线照射小鼠损伤效应。材料与方法： 通过预先给予NAC，观察其对受照小鼠的骨髓造血功能和免疫功能的影响。结果： NAC具有保护和提高受照小鼠骨髓有核细胞数，CFU-S，CFU-GM及胸腺细胞自发增殖能力和脾细胞产生白细胞介素(IL-2)的能力。结论： NAC可提高小鼠对X射线照射损伤的耐受能力。
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| 关 键 词： | N-乙酰左旋半胱氨酸 X射线 损伤 |
| 文章编号： | 1004-616X(2004)04-0223-03 |
| 收稿时间： | 2004-01-04 |
| 修稿时间： | 2004-01-04 |
Studies on Antiradiation Effect of N-acetylcysteine in X-irradiated Mouse |
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| AN Zhi-guo,WANG Xin,LIU Zhong-xiang. Studies on Antiradiation Effect of N-acetylcysteine in X-irradiated Mouse[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2004, 16(4): 223-225. DOI: 10.3969/j.issn.1004-616x.2004.04.011 |
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| Authors: | AN Zhi-guo WANG Xin LIU Zhong-xiang |
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| Affiliation: | China-Japan Union Hospital JiLin University, Changchun 130033,China |
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| Abstract: | BACKGROUND&AIM: Studies on antiradiation effect of N_acetylcysteine in X_irradiated mouse.MA TERIAL AND METHODS: In this dissertation,the antiradiation effect of pretreated NAC to mouse before X_irradiation were studied heamopoietic and immunological functions. RESULTS: NAC not only improve differentiation and proliferation of CFU_S,CFU_GM in bone marrow of mouse but also increase significantly the Con A_induced proliferation reaction of splenocytes and the spontaneous proliferation and the production of IL_2of splenocytes induced by Con A in mouse exposed to different doses X_rays. CONCLUSION: NAC can increase significantly tolerance ability of antiradiation in mouse exposed to different doses x-rays. |
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| Keywords: | N-acetylcysteine X-ray damnification |
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