脑囊虫病患者血清和脑脊液IL-6和SIL-2R的水平及其与癫痫发作的关系

目的测定脑囊虫病患者血清和脑脊液IL-6和SIL-2R水平,并探讨其与癫痫发作的关系。方法应用双抗体夹心ELISA法测定45例脑囊虫病患者和43例对照组患者血清和脑脊液IL-6利SIL-2R的水平,其中脑囊虫病组又分为癫痫组(23例)和非癫痫组(22例),分别进行了比较分析。结果脑囊虫病组血清SIL-2R水平明显高于对照组(P<0.05);而IL-6水平与对照组比较无显著性差异(P>0.05)。脑囊虫病组脑脊液SIL-2R和IL-6水平均较对照组低(P<0.01,P<0.05);脑囊虫病组血清SIL-2R和IL-6水平与脑脊液SIL-2R和IL-6水平均呈正相关(r=0.322,P<0.05;r=0.768,P<0.01)。脑囊虫病癫痫组血清SIL-2R和IL-6水平与非癫痫组比较均无显著性差异(P>0.05);而脑脊液SIL-2R和IL-6水平癫痫组明显高于非癫痫组(P<0.01)。结论脑囊虫病患者外周血和中枢神经系统存在免疫激活,且SIL-2R和IL-6可能参与了癫痫发生过程。

The Detection of SIL-2R and IL-6 serum And CSF in Patients with Cerebral Cysticercosis and the relations with epilepsy seizures

Objective: To investigate the concentration of SIL-2R and IL-6 in paired serum and cerebrospinal fluid(CSF) from 45 patients 'with cerebral cysticercosis, and to evaluate the relation with epilepsy seizures. Methods: SIL-2R and IL-6 were measured by ELISA ill paired serum and CSt: fi'om 45 patients with cerebral cysticercosis and 43 references. The patients were divided into two groups according to clinical manifestations: epilepsy and nonepilepsy group. Results: The SIL-2R level in the serum of neurocysticercosis patients was obviously higher than that of control group (P<0.05); in the CSF, SIL-2R and IL-6 levels are lower than controls (P<0.05); in neurocysticercosis group, SIL-2R and IL-6 levels of serum have positive correlations with those of CSF(separately r=0.322 and r=0.768,P<0.05); in CSF of the epilepsy group, SIL-2R and IL-6 levels are higher than the nonepilepsy group (P<0.01). Conclusions: In neurocysticercosis patients, the immune and inflammation response SIL-2R and IL-6 maybe participate in the happening process of epilepsy.