| 3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚对体外培养心肌细胞作用的研究 |
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| 引用本文： | 臧玉英, 王道生, 曹观坤. 3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚对体外培养心肌细胞作用的研究[J]. 中国现代应用药学, 1991, (1): 1-4. |
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| 作者姓名： | 臧玉英 王道生 曹观坤 |
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| 作者单位： | 苏州医学院药理教研室，苏州医学院药理教研室，中国药科大学制药化学教研室 江苏省苏州市 215007，江苏省苏州市 215007，江苏省南京市 210009 |
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| 摘 要： | 3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚(N22)为苯酚的衍生物,属非甾体类抗炎药。本文研究了N22对体外培养心肌细胞的作用,结果表明N22对大鼠体外培养心肌细胞搏动有明显的负性频率作用,并伴有搏动强度减弱作用;对自发性或由乌豆碱诱发的速发型心律失常有明显的对抗作用。
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| 关 键 词： | 3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚 培养心肌细胞 负性频率 心律失常 |
Effects of 3-[4-2(hydroxyethyl) piperazinyl] methyl-P-dihydoxydiphenyl on Cultured Heart Cells in vitro |
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| Zang Yuying et al, . Effects of 3-[4-2(hydroxyethyl) piperazinyl] methyl-P-dihydoxydiphenyl on Cultured Heart Cells in vitro[J]. Chinese Journal of Modern Applied Pharmacy, 1991, (1): 1-4. |
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| Authors: | Zang Yuying et al. |
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| Abstract: | 3-[4-2(hydroxyethyl) piperazinyl] methyi-P-dlhydoxydiphenyl derived from phenol was a nonsteroidal antimflammatory drug possessing antimflammatory and antipyretic-analgesic activities. Effect of 3-[4-2(hydroxyethyl)piperazingl] methyl-P-dihydoxydiphenyl on cultured neonatal rat heart cells were investigated. It was shown that 3-[4-2(hydroxyethyl)piperezinyl] methyl-Pdihydoxydlphenyl had the significant negative chronotropic and negative inotropic actions, It significantly inhibited spontaneous and aconitine-induced tachyrrythmias in cultured myocardial cells. |
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| Keywords: | 3-[4-2(hydroxyethyl) piperazingl] methyl-P-dihydoxydiphenyl cultured myoca-rdial cells negative chronotropic action tachyarrhythmia |
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