Determination of saliva: total plasma chloroquine levels relationship by high performance liquid chromatography |
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| Authors: | E A Brown-Awala W O Thomas E E Essien E I Ette |
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| Affiliation: | Department of Clinical Pharmacy and Biopharmacy, School of Pharmacy, College of Medicine, University of Lagos, Nigeria. |
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| Abstract: | The use of saliva chloroquine concentrations measurement as a noninvasive technique in the evaluation of the pharmacokinetics of the drug was investigated. Chloroquine concentrations in saliva and plasma were measured in eight healthy volunteers after a single oral dose of two tablets of chloroquine sulfate. The saliva: total plasma concentrations (S/P) ratio was found to be approximately constant in the absorption (0.4 +/- 0.07), distribution (0.47 +/- 0.08), and elimination (0.46 +/- 0.05) phases. Thus, saliva sampling for chloroquine concentrations was found to be a useful noninvasive technique for the estimation of all the pharmacokinetic parameters of the drug and hence, for chloroquine pharmacokinetic studies. |
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