Excitatory amino acids increase glycogen phosphorylase activity in the rat spinal cord |
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| Authors: | C J Woolf |
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| Affiliation: | 1. Dipartimento di Farmacia, Università degli Studi di Parma, I-43124 Parma, Italy;2. Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, United States;3. Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, United States;4. Unit of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy;1. Molecular and Translational Neuroscience, Department of Neurology, Ulm University, 89081 Ulm, Germany;2. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany;3. Institute of Neuronal Cell Biology, Technical University Munich, 80805 Munich, Germany;4. German Center for Neurodegenerative Disease (DZNE), 81377 Munich, Germany;5. Max Planck Institute of Experimental Medicine, Cellular Neuroscience, 37075 Göttingen, Germany;1. Departments of Anatomy and Neurobiology, University of California Irvine, Irvine, California;2. Neurobiology and Behavior, University of California Irvine, Irvine, California;3. Biological Chemistry, University of California Irvine, Irvine, California;4. Pharmaceutical Sciences, University of California Irvine, Irvine, California;5. Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California |
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| Abstract: | Glycogen phosphorylase is present in nervous tissue in an active and inactive form. Using a histochemical technique, an investigation into which putative neurotransmitters have the capacity to modify the activity of the enzyme, has been performed on the rat spinal cord. Intrathecal injections of L-glutamate and L-aspartate elevate glycogen phosphorylase activity in the dorsal horn, while substance P has no effect and only high doses of adenosine triphosphate (ATP) increase the enzyme activity. In addition the N-methyl-D-aspartate receptor antagonist, 5-amino-phosphonovaleric acid was found to block the elevation of glycogen phosphorylase activity in the dorsal horn produced by the peripheral activation of chemo-sensitive primary afferents. Excitatory amino-acid neurotransmitters can therefore, acting via second messengers and protein kinases, modify glycogen metabolism in the spinal cord. |
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