阻塞性睡眠呼吸暂停低通气综合征患者植物凝集素样氧化低密度脂蛋白受体-1及血脂水平的研究

目的 探讨不同程度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者体内植物凝集素样氧化低密度脂蛋白受体-1（LOX-1）及血脂的水平.方法 对2011年1月-7月间具有睡眠障碍症状的门诊患者94例进行多导睡眠图（PSG）监测,根据睡眠呼吸暂停低通气指数（AHI）分为3组,轻中度OSAHS组（5次/h≤AHI≤30次/h）27例,重度OSAHS组（AHI＞ 30次/h）37例,正常对照组（AHI＜5次/h）30例,均检测血清LOX-1、TG、TC、HDL-C、LDL-C.结果 重度OSAHS组血清LOX-1水平最高,轻中度组、正常对照组依次减低,差异有统计学意义（P＜0.01）.OSAHS患者血清LOX-1水平与AHI、夜间最长呼吸暂停时间（LAT）呈正相关（r值分别为0.645、0.501,P＜0.01）,与夜间最低血氧饱和度（SaO2）呈负相关（r=-0.647,P＜0.01）.OSAHS组患者血脂水平与正常对照组差异无统计学意义（P＞0.05）.结论 OSAHS所造成的夜间间歇缺氧可导致血清LOX-1水平升高,血脂水平不能有效预测OSAHS患者脂代谢紊乱的程度.

Study of serum LOX-1 and lipids in patients with obstructive sleep apnea hypopnea syndrome

Objective To explore the changes of serum lectin-iike oxidized low-density lipoprotein receptor-1 （LOX-1） and the level of lipids in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods A total of 94 candidates with sleep disorders between January-July 2011 at outpatient department were monitored with polysomnography. According to apnea-hypopnea index （AHI） , they were divided into mild-to-moderate OSAHS （ 5 ~〈 AHI ~〈 30） （ n = 27 ）, severe OSAHS （ AHI 〉 30） （ n = 37 ） and normal control groups （AHI 〈 5 ） （n = 30 ）. After polysomnography, their blood samples were obtained to measure the levels of serum LOX-1, triglycerides （TG）, cholesterol （TC）, high-density lipoprotein （HDL-C） and low-density lipoprotein （LDL-C）. Results The serum level of LOX-1 in severe OSAHS group was significantly higher than that in the mild-to-moderate and control groups （P 〈 0.01 ）. The serum level of LOX-I in OSAHS patients was positively correlated with AHI and longest apnea time （ LAT ） （ r = 0. 645 ＆ 0. 501 respectively, both P 〈 0.0l ） and was negatively correlated with SaO2 （ r = - 0. 647, P〈0.01）. No significant difference existed in serum lipids in all groups （P 〉 0. 05）. Conclusions Intermittent hypoxia caused by OSAHS increases the level of LOX-1 to further promote the formation and development of atherosclerotic in patients with OSAHS. The levels of lipid can not effectively predict the severitv of lipid metabolism disorder in patients with OSAHS.