中药丹参、川芎联合强的松治疗特发性肺纤维化的临床疗效

目的丹参、川芎嗪治疗大白鼠肺纤维化模型获良好疗效，应用于临床。方法将确诊为特发性肺纤维化(IPF)者分为两组联合组为丹参、川芎联合强的松治疗，对照组单用强的松治疗。结果治疗后1个月、6个月随访，呼吸困难、咳嗽两组都有明显好转。胸部X线阴影、肺功能联合组20%有轻微吸收与改善，对照组为10%。呼吸道感染对照组较多。随访24个月联合组稳定73%，恶化27%，无死亡。对照组稳定60%，恶化30%，死亡10%。结论丹参、川芎联合强的松治疗IPF，24个月后观察长期疗效，病情稳定，感染次数减少，免疫功能增加，病死率降低优于单纯强的松组。

TO EVALUATE THE EFFICACY OF LIGUSTRAZIN AND SALVIA MILTIORRHIZA COMBINED PREDNISONE TO TREAT IDIOPATHIC PULMONARY FIBROSIS

Objective:Use ligustrazin and salvia miltiorrhiza to treat idiopathic pulmonary fibrosis,for the experimental result was perfect in animal modal.Method:These two drugs combined with prednisone in 15 patients as treated group,prednisone in 10 patients as control group.Result:At 1,6 months followed up,the dyspnea and cough improved markedly.Chest radiograph and pulmonary function improved slightly.There were no differences between two groups.After 24 month the combined group 13(73%) stabilized,4(27%) relapse or deterioration,no death.Control group 6(60%) stabilized,3(30%) relapse or deterioration,1(10%) death,Conclusion:Combined group was better then control group.Ligustrazin and salvia miltorrhiza could decrease alveolitis and inhibit the formation of procollagen.It also improve the patient's immunity.