星状神经节阻滞治疗围绝经期失眠症26例疗效分析

目的观察星状神经节阻滞治疗围绝经期失眠症患者的临床疗效。方法选择我院门诊及住院确诊为围绝经期失眠症的患者26例,采用前入路径行星状神经节阻滞(SGB)治疗20次,观察睡眠改善情况,检测治疗前后血雌二醇(E2),促卵泡生成素(FSH)、黄体生成素(LH)的变化,用汉密尔顿焦虑量表(HamiltonanxietyscaleHAMA)评定患者焦虑症状的严重程度。结果血中E2由治疗前的(33.13±18.26)pmol/L升至(153.64±86.57)pmol/L(t=-8.00,P<0.01),FSH由治疗前的(52.74±20.16)U/L降至(37.96±12.48)U/L(t=2.08,P<0.05),LH由治疗前的(36.09±13.34)U/L降至(25.35±7.51)U/L(t=2.21,P<0.05)。睡眠改善的总有效率为84.6%。HAMA评分由治疗前的(19.9±6.87)分降至(11.4±4.1)分(t=3.35,P<0.01)。结论 GB治疗能有效改善患者失眠和焦虑症状,能调节围绝经期失眠症患者的神经平衡失调。

Effect of stellate ganglion block in the treatment of 26 perimenopausal patients with insomnia

Objective To explore the clinical effect of stellate ganglion block (SGB) in the treatment of perimenopausal patients with insomnia. Methods Twenty-six perimenopausal patients diagnosed as insomnia in the Central Hospital of Enshi were treated by SGB for 20 times via the anterior approach. The improvements of sleep was observed, the severity of anxiety symptoms was evaluated by Hamilton Anxiety Scale (HAMA), and the changes of blood estradiol (E2), Follicle-Stimulating Hormone (FSH) and luteinizing hormone (LH) were detected. Results The serum level of E2 increased from (33.13±18.26) pmol/L to (153.64±86.57) pmol/L (t=-8.00, P<0.01), FSH decreased from (52.74±20.16) U/L to (37.96±12.48) U/L (t=2.08, P<0.05), and LH reduced from (36.09±13.34) U/L to (25.35±7.51) U/L (t=2.21, P<0.05). The total efficient rate of improvement of sleep was 84.6%, and the HAMA score decreased from (19.9±6.87) to (11.4±4.1) (t=3.35, P<0.01). Conclusion SGB can regulate perimenopausal patients with insomnia in nervous imbalance, and it may be effective in improving insomnia.