夫精宫腔内人工授精周期数与妊娠率的相关性分析

目的分析夫精宫腔内人工授精(IUI)治疗周期数与临床结局的相互关系。方法回顾性分析2196个IUI周期的病例资料,比较治疗周期次数与临床妊娠率的关系。结果 1625例患者行2196个IUI周期,有329例获临床妊娠,周期妊娠率为15%,夫妇累积妊娠率为20.2%。第1、第2、第3、第4周期组的临床妊娠率分别为15.2%、14.9%、12.9%、0.0%,各组间比较差异无统计学意义(P>0.05);1、2、3、4个周期组的周期临床妊娠率分别为19.7%、10.1%、8.9%、6.3%,累积妊娠率分别为19.7%、20.2%、26.7%、25.0%。两两比较分析显示1个周期组与2个周期组及3个周期组的周期临床妊娠率差异均有统计学意义(P<0.01),但其他组间比较差异无统计学意义(P>0.05);各组间累积妊娠率比较差异无统计学意义(P>0.05)。结论 IUI治疗中适当增加助孕周期数可以增加累积临床妊娠率。

Correlation analysis on the pregnancy outcome and cycles of intrauterine insemination with husband sperm

Objective To explore the correlation between the cycles of intrauterine insemination (IUI) with husband sperm and the pregnancy outcome. Methods A total of 2 196 IUI cycles were analyzed retrospectively. The relationship between the number of cycles of IUI and pregnancy rate was analyzed. Results 1 625 infertile couples were treated with 2 196 cycles of IUI. 329 cases were found with pregnancy. The pregnancy rate (PR) was 15% per cycle and 20.2% per couple. The clinical PR for the first, second, third and fourth cycle were 15.2%, 14.9%, 12.9% and 0.0%, respectively, with no statistically significant differences (P>0.05). The cycle PR for the one cycle, two cycle, three cycle, four cycle were 19.7%, 10.1%, 8.9%, 6.3%, respectively, with statistically significant difference between the one, two, three cycle. The cumulative pregnancy rates for the four groups were 19.7%, 20.2%, 26.7%, 25%, respectively, with no statistically significant differences (P>0.05). Conclusion Adding IUI cycles properly could increase the clinical pregnancy rate.