糖尿病合并脂肪肝的临床特征分析

目的探讨糖尿病合并脂肪肝临床特征,寻找相关危险因素。方法 2006年11月至2011年2月在我院门诊及住院治疗的108例2型糖尿病患者分为两组,其中合并非酒精性脂肪肝组(NAFL组)52例,不合并非酒精性脂肪肝组(非NAFL组)56例,检测体重指数、腰围、收缩压、舒张压、空腹血糖、空腹胰岛素、血胰岛素抵抗指数、糖化血红蛋白、谷丙转氨酶酶、谷草转氨酶、C反应蛋白、尿酸、总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白等相关因素并组间比较,NAFL与各种影响因素间相关性检验用Logistic多因素逐步回归分析。结果 NAFL组BMI、腰围、FBG、FINS、GHbA1c、UA、TC、TG、HDL及LDL水平与非NAFL组比较,差异有统计学意义(P<0.05或P<0.01);BMI、腰围、TG及LDL与NAFL发生密切相关。结论 BMI、腰围、TG及LDL是发生2型糖尿病合并NAFL的高危因素。

Clinical feather of diabetes combined with fatty liver

Objective To investigate the clinical features of diabetes combined with fatty liver (NAFL) and its risk factors. Methods 108 cases with type 2 diabetes patients from November 2006 to February 2011 were divided into two groups, there were 52 cases in NAFL group and 56 cases in the non-NAFL group, the body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose (FBG), fasting insulin (FINS), insulin resistance index, glycosylated hemoglobin (GHBA1c), enzymes alanine aminotransferase, aspartate aminotransferase, C-reactive protein, uric acid (UA), total cholesterol (TC), triglycerides, low density lipoprotein (LDL) and high density lipoprotein (HDL) and other related factors were detected and compared. Logistic multivariate regression analysis were used to process the correlation between NAFL and the various factors. Results Compared with the non-NAFL group, there were significant difference between BMI, waist circumference, FBG, FINS, GH- bA1c, UA, TC, TG, HDL and LDL levels (P<0.05 or P<0.01), there were closely correlation between the occurrence of NAFL and BMI, waist circumference, TG and LDL. Conclusion BMI, waist circumference, TG and LDL are risk factors of type 2 diabetes combined with NAFL.