Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease |
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| Authors: | Spiecker Martin Liao Jamesk |
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| Affiliation: | Department of Medicine II, St. Josef-Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany. |
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| Abstract: | Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease. |
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