吸入麻醉药后处理心肌保护作用机制的研究进展

背景 吸入麻醉药后处理(inhalational anesthetics postconditioning,APO)是指在缺血后冉灌注早期给予一定浓度吸入麻醉药处理.APO具有心肌保护作用,其作用机制目前尚未完全阐明.目的 对APO心肌保护作用机制的研究进展进行回顾和总结.内容 APO的心肌保护的信号转导机制与缺血后处...

Progress in research of cardioprotective mechanisms of inhalational anesthetics postconditioning

Background Inhalational Anesthetics Postconditioning (APO) provides inhalational anesthetics of certain concentration at the early stage of reperfusion after myocardial ischemia. APO can apparently protect ischemia/reperfusion myocardium, but its mechanism has not been fully understood. Objective In this paper, we have reviewed the latest progress of the cardioprotective mechanisms of APO. Content The signal transduction of APO is similar to ischemia-induced postconditioning. APO may stimulate myocardium to produce triggers to activate relevant signaling pathways, and eventually activate effectors. Multiple studies have demonstrated that activation of reperfusion injury salvage kinase (RISK), control of cardiocyte apoptosis during reperfusion, opening of mitochondria ATP-sensitive potassium channels (mitoKATP), mitochondrial permeability transition pore (mPTP) opening inhibition are involved in the cardioprotective effects of APO. Trend The cardioprotective mechanisms of APO are complicated. Fully understand these complex mechanisms of signal transduction will be helpful to illuminate the principle of APO and promote its clinical application.