| 钙ATP酶在豚鼠过敏性哮喘发病过程中的作用 |
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| 引用本文： | 孙宝君,董伟.钙ATP酶在豚鼠过敏性哮喘发病过程中的作用[J].军医进修学院学报,1994,15(3):193-196. |
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| 作者姓名： | 孙宝君 董伟 |
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| 摘 要： | 本实验给致敏豚鼠吸入卵蛋白建立速发型过敏性哮喘的动物模型，观察了呼吸系总阻抗（Ｚｒｓ）及豚鼠肺组织钙ＡＴＰ酶（Ｃａ２＋－ＡＴＰａｓｅ）活性的变化以及６５４－２，异搏定对二者的影响。结果表明哮喘组Ｚｒｓ明显高于正常组（Ｐ＜０．０１），肺组织Ｃａ２＋－ＡＴＰａｓｅ活性明显低于正常组（Ｐ＜０．０１），６５４－２有增Ｃａ２＋－ＡＴＰａｓｅ活性的作用。说明在过敏性哮喘的发病过程中Ｃａ２＋－ＡＴＰａｓｅ活性下降是其病理生理变化的一个重要因素，细胞内钙浓度升高可能与此有关。
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| 关 键 词： | 哮喘 病因学 山莨菪硷 维拉帕米 豚鼠 |
The Role of Ca2 -ATPase in the Pathogenesis of Allergic Asthma inGuinea Pigs |
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| Sun
Baojun,Huang Nianqu,Dong Wei,Li Xinjian.The Role of Ca2 -ATPase in the Pathogenesis of Allergic Asthma inGuinea Pigs[J].Academic Journal of Pla Postgraduate Medical School,1994,15(3):193-196. |
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| Authors: | Sun
Baojun Huang Nianqu Dong Wei Li Xinjian |
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| Institution: | Department of Pulmonary Me-dicine |
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| Abstract: | The
immeditate-type of allergic asthma animal model was established in sensitized gu- inea pigs
by inhalation with ovalbumin. Respiratory impedance(Zrs),activity of Ca2 -ATPase in lung
tissue,effect of anisodamine (654-2) and verapamil on them were observed,The results
sho-wed that Zrs in asthma group was increased than that in normal group (P<0.01),that activity
of Ca2 -ATPase in lung tissue of asthma group was lower than that of normal group
(P<0.01).The results suggested that decrease of Ca2 -ATPase activity in lung tissue may be an
important factor in the pathogenesis of the allergic asthma. The increase of intracellular
Ca2 may relate to decrease of Ga2 -ATPase activity.Anisodamine can increase Ca2 -ATPase
activity.Verapamil has no effect on Ca2 -ATPase activity. |
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| Keywords: | asthma etiology anisodamine verapamil adenosine triphosphatase calcium guinea pigs |
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