| 西拉普利（Cilazapril）对自发性高血压大鼠动脉内膜损害的逆转作用 |
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| 引用本文： | 黄少华,苏诚坚,曾昭华. 西拉普利（Cilazapril）对自发性高血压大鼠动脉内膜损害的逆转作用[J]. 广东药学院学报, 1995, 0(2) |
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| 作者姓名： | 黄少华 苏诚坚 曾昭华 |
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| 作者单位： | 广州医学院，广州医学院第一附属医院心血管内科 |
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| 摘 要： | 为了探讨血管紧张素转换酶抑制剂（ＡＣＥＩ）对原发性小动脉内膜损害的逆转作用，本文用透射电子显徽镜观察３－６个月的自发性高血压大鼠（ＳＨＲ）和正常血压对照大鼠（ＷＫＹ）肠系膜动脉内膜的超徽结构；及新一代ＡＣＥＩ西拉普利（Ｃｉｌａｚａｐｒｉｌ）治疗对这种损害的影响，结果显示：①与ＷＫＹ相比，ＳＨＲ肠系膜动脉内膜腔面有白细胞（ＷＢＣ）粘附、侵袭、内膜下空间增宽，内皮细胞中线粒体增多、肿胀、变性。②Ｃｉｌａｚａｐｒｉｌ治疗三个月后ＳＨＲ血压得到有效控制，死亡率明显下降，以上血管内膜改变减轻或消失。提示原发性高血压血管内膜有超徽结构损害，Ｃｉｌａｚａｐｒｉｌ治疗能逆转这种血管损害。
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| 关 键 词： | 原发性高血压，血管内膜，超徽结构，西拉普利 |
The Reversal Function of Cilazapril to the Inner Membrane Lesions of Artery in Rat with Essention Hypertension |
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| Huang Shaohua,Su Cheng jian and Zeng Chaohua. The Reversal Function of Cilazapril to the Inner Membrane Lesions of Artery in Rat with Essention Hypertension[J]. Academic Journal of Guangdong College of Pharmacy, 1995, 0(2) |
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| Authors: | Huang Shaohua Su Cheng jian Zeng Chaohua |
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| Abstract: | In this paper,the ultrastructrue of arterial inner membrane of rat with essential hy-pertension was studied with transmission electronmicrorcope and the reversal function of cilazapril tothe ultrastructural lesions was investigated.It was shown that the major alterations were adherenceandinvasion of WBC to arterial inner membrane,broadened subendothelium, mitochondrial enlarge-ment,degeneration and increase in number.It was found that these lesions could be reversed and thedeath rate of rat with essential hypertension lowered when treated with cilazapril. |
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| Keywords: | cliazapril essential hypertension arterial ultrastructure |
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