Schistosoma mansoni: preclinical studies with 9-Acridanone-hydrazones in Cebus monkeys experimentally infected. |
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Authors: | P M Coelho L H Pereira |
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Affiliation: | Departamento de Parasitologia, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, Brasil. |
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Abstract: | Derivatives of acridine (9-Acridanone-hydrazones) were tested in Cebus monkeys experimentally infected with Schistosoma mansoni, at the dosages of 50, 25, and 12.5 mg/kg (p.o., single dose). At least, four compounds seemed to be very promising, promoting alterations in the oogram and reducing the worm burden drastically, even at the lowest dose (12.5 mg/kg). No side effects could be detected after drug administration. |
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