| Adenoviral gene therapy in gastric cancer： A review |
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| 引用本文： | Khalighinejad N,Hariri H,Behnamfar O,Yousefi A,Momeni A. Adenoviral gene therapy in gastric cancer： A review[J]. World journal of gastroenterology : WJG, 2008, 14(2): 180-184. DOI: 10.3748/wjg.14.180 |
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| 作者姓名： | Khalighinejad N Hariri H Behnamfar O Yousefi A Momeni A |
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| 作者单位： | Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran,Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran,Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran,Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran,Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran |
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| 摘 要： | Gastric cancer is one of the most common malignancies worldwide. With current therapeutic approaches the prognosis of gastric cancer is very poor, as gastric cancer accounts for the second most common cause of death in cancer related deaths. Gastric cancer like almost all other cancers has a molecular genetic basis which relies on disruption in normal cellular regulatory mechanisms regarding cell growth, apoptosis and cell division. Thus novel therapeutic approaches such as gene therapy promise to become the alternative choice of treatment in gastric cancer. In gene therapy, suicide genes, tumor suppressor genes and anti-angiogenesis genes among many others are introduced to cancer cells via vectors. Some of the vectors widely used in gene therapy are Adenoviral vectors. This review provides an update of the new developments in adenoviral cancer gene therapy including strategies for inducing apoptosis, inhibiting metastasis and targeting the cancer cells.
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| 关 键 词： | 胃癌 腺病毒 基因治疗 肿瘤转移 细胞凋亡 |
| 收稿时间： | 2007-07-21 |
Adenoviral gene therapy in gastric cancer: a review |
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| Khalighinejad Nima,Hariri Hesammodin,Behnamfar Omid,Yousefi Arash,Momeni Amir. Adenoviral gene therapy in gastric cancer: a review[J]. World journal of gastroenterology : WJG, 2008, 14(2): 180-184. DOI: 10.3748/wjg.14.180 |
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| Authors: | Khalighinejad Nima Hariri Hesammodin Behnamfar Omid Yousefi Arash Momeni Amir |
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| Affiliation: | Isfahan University of Medical Sciences,Khalighinejad Nima,Number 111,5th street,Mardavij Street,Isfahan,Iran |
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| Abstract: | Gastric cancer is one of the most common malignancies worldwide. With current therapeutic approaches the prognosis of gastric cancer is very poor, as gastric cancer accounts for the second most common cause of death in cancer related deaths. Gastric cancer like almost all other cancers has a molecular genetic basis which relies on disruption in normal cellular regulatory mechanisms regarding cell growth, apoptosis and cell division. Thus novel therapeutic approaches such as gene therapy promise to become the alternative choice of treatment in gastric cancer. In gene therapy, suicide genes, tumor suppressor genes and anti-angiogenesis genes among many others are introduced to cancer cells via vectors.Some of the vectors widely used in gene therapy are Adenoviral vectors. This review provides an update of the new developments in adenoviral cancer gene therapy including strategies for inducing apoptosis, inhibiting metastasis and targeting the cancer cells. |
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| Keywords: | Gastric cancer Adenovirus Gene therapy Vector Apoptosis Metastasis |
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