Peripheral blood stem cell mobilization using high-dose cyclophosphamide and G-CSF in pretreated patients with lymphoma |
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| Authors: | Jenny I. O. Craig Robert S. Anthony Anne Stewart Eric B. Thomson Jack Gillon Alistair C. Parker |
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| Affiliation: | Department of Haematology, The Royal Infirmary of Edinburgh, Scotland;*South East Scotland Blood Transfusion Service, The Royal Infirmary of Edinburgh, Scotland |
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| Abstract: | Summary. Peripheral blood stem cell (PBSC) mobilization for autologous transplantation is more difficult in treated patients and those with bone marrow involvement. In 17 pretreated lymphoma patients, cyclophosphamide (4 g/m2) and G-CSF mobilized a median circulating peak of 1959 CFU-GM/ml on day 12.5. PBSC harvesting commenced when WBC was 1×109/l at day 10.5 collected a median of 21.2 × 104/CFU-GM/kg. 13/17 (76%) patients exceeded the 10 × 104 CFU-GM/kg threshold for engraftment. The CFU-GM yield was significantly higher in patients whose WBC recovered from 1–5 × 109/1 in less than 3 days and correlated with the maximum WBC pre and post the cyclophospharnide induced nadir. This regime safely mobilized adequate PBSC in the majority of pretreated lymphoma patients. |
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