复方木尼孜其颗粒治疗黄褐斑临床疗效观察及安全性评价

目的:探讨复方木尼孜其颗粒治疗黄褐斑临床疗效及安全性评价,为临床诊断治疗提供参考。方法:将本组120例黄褐斑患者根据随机数字表法随机分为对照组(n=60)和观察组(n=60)。观察组给予复方木尼孜其颗粒治疗,对照组口服维生素C、维生素E治疗。两组均以1个月为1个治疗疗程,两个疗程后观察疗效。结果:观察组治疗后总有效率(78.33%)显著高于对照组(55.00%),且具有显著性差异(P<0.05);两组患者治疗前FSH、LH、E2比较无显著性差异(P>0.05);观察组患者治疗后FSH、LH、E2均明显低于治疗前,且具有显著性差异(P<0.05);观察组治疗后LH、E2显著低于对照组治疗后,且有显著性差异(P<0.05);而FSH比较两组变化无显著性差异(P>0.05);观察组治疗后MCI值显著低于对照组,且有显著性差异(P<0.05);两组患者均未出现明显的不良反应。结论:复方木尼孜其颗粒治疗黄褐斑临床疗效显著,可明显改善患者皮损区皮肤,具有重要临床研究价值,值得推广应用。

Clinical Efficacy and Safety Evaluation of Compound Muni Ziqi Particle in Treatment of Chloasma

Objective： To investigate the clinical efficacy and safety evaluation of Compound Muni Ziqi Particle in the treatment of chloasma and to provide a reference for clinical diagnosis and treatment. Methods： 120 patients were randomly divided into control group（ n = 60） and observation group（ n = 60） based on a random number table. The observation group was given Compound Muni Ziqi Particle and the control group was treated with vitamin C and vitamin E. Both groups were treated for a month as a course of treatment and we observed the efficacy of the two treatments. Results： The total treatment efficiency（ 78. 33%） was significantly higher than that（ 55. 00%） of the control group and has a significant difference（ P〈0. 05）. Before treatment,two groups＇ FSH,LH and E2 had no significant difference（ P〉0. 05）.After treatment,FSH,LH and E2 were significantly lower than those before treatment and had significant difference（ P〈0. 05）. In observation group after treatment,LH and E2 were significantly lower than those of the control group after treatment and there was a significant difference（ P〉0. 05） while FSH changes had no significant difference（ P〈0. 05）.MCI value of the observation group was significantly lower than that of the control group and there was a significant difference（ P〈0. 05）. Two patients had no obvious adverse reactions. Conclusion： Compound Muni Ziqi Particle treatment of chloasma has clinically significant effect and can significantly improve patients＇ lesion skin and has important clinical research value and should be widely applied.