Effects of intravitreal perfusion with dopamine in different concentrations on the DC electroretinogram and the standing potential of the albino rabbit eye |
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Authors: | Ola Textorius Dr Sven Erik G Nilsson Björn-Erik Andersson |
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Institution: | (1) Department of Ophthalmology, University of Linköping, Linköping, Sweden;(2) Department of Ophthalmology, University of Linköping, S-581 85 Linköping, Sweden |
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Abstract: | The direct current electroretinogram and the standing potential were recorded from both eyes of 23 albino rabbits during intraocular perfusion of one of the eyes, which was vitrectomized, with a physiologic reference solution (PHS). PHS was then replaced by a test solution containing dopamine dissolved in PHS. The fluids were subsequently alternated (PHS-dopamine-PHS). During irrigation with 0.25–0.5 mM dopamine (11 rabbits) the c-wave amplitude was 140% higher (p < 0.001) and during irrigation with 25 mM dopamine (6 rabbits) 85% lower (p < 0.01) than it was during the corresponding initial perfusion with PHS. The simultaneously recorded b-wave amplitude was reduced (0.25–0.5 mM: -22%, p < 0.001; 25 mM: - 69%, p < 0.001) and the SP level increased (0.25–0.5 mM: +2375 V, p < 0.01; 25 mM: +2530 V, p < 0.05) compared with the values obtained during the corresponding preceding irrigation with PHS. Thus the changes in the b- and c-wave amplitudes during perfusion with dopamine were dependent on the concentration of the drug. In the contralateral control eye (23 rabbits) the c-wave amplitude was 21% higher (p < 0.001), the b-wave amplitude 14% higher (p < 0.001) and the standing potential 1007 V higher (p < 0.001) during intravitreal perfusion with dopamine in the other eye than during the preceding irrigation with PHS in that eye, possibly as a result of increasing dark adaptation. |
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Keywords: | b-wave c-wave dopamine electroretinogram neurotransmitter standing potential |
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