| 龙血竭中龙血素A在大鼠体内的药动学研究 |
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| 引用本文： | 易军,金描真,孙晓博,乔淑娟.龙血竭中龙血素A在大鼠体内的药动学研究[J].广东药学院学报,2010,26(5):452-454. |
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| 作者姓名： | 易军 金描真 孙晓博 乔淑娟 |
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| 作者单位： | 广东药学院,药科学院,广东广州,510006 |
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| 基金项目： | 广东省中医药管理局项目，国家中医药管理局项目 |
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| 摘 要： | 目的考察龙血竭中龙血素A在大鼠体内的药动学行为。方法按100 g大鼠给予龙血竭250 mg灌胃给药,测定不同时间点的血药浓度,并以3P97软件计算其药动学参数。结果龙血素A的Ka为（1.46±0.19）h-1,t1/2（Ka）为（0.48±0.06）h,t1/2（K）为（2.59±0.67）h,tmax为（2.00±0.55）h,Cmax为（1.13±0.24）μg.mL-1,AUC为（2.84±0.68）μg.h.mL-1。结论龙血素A在大鼠体内符合线性动力学一室开放模型,吸收较快。
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| 关 键 词： | 龙血竭 龙血素A 高效液相色谱法 大鼠 药动学 |
Study on pharmacokinetics of loureirin A in rats |
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| YI Jun,JIN Miao-zhen,SUN Xiao-bo,QIAO Shu-juan.Study on pharmacokinetics of loureirin A in rats[J].Academic Journal of Guangdong College of Pharmacy,2010,26(5):452-454. |
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| Authors: | YI Jun JIN Miao-zhen SUN Xiao-bo QIAO Shu-juan |
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| Institution: | (School of Pharmacy,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China) |
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| Abstract: | Objective To study on pharmacokinetics of loureirin A in rats.Methods The blood samples were collected at a series of time points after an oral administration of Dragon′s blood to rats（2.5 g·kg-1）,and were analyzed by HPLC.Pharmacokinetic parameters were valuated by 3P97 software.Results Pharmacokinetic parameters of loureirin A were as follows：Ka（1.46±0.19） h-1,t1/2（Ka）（0.48±0.06） h,t1/2（K）（2.59±0.67） h,tmax（2.00±0.55） h,Cmax（1.13±0.24） μg·mL-1,AUC（2.84±0.68） μg·h·mL-1.Conclusion The results demonstrated that the pharmacokinetics of loureirin A was consistent with one-compartment model,which was absorbed and distributed rapidly in rats. |
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| Keywords: | Dragon′s blood loureirin A HPLC pharmacokinetics |
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