| 消淤片对粥样硬化兔血清LDL电泳迁移速度及含TC和TG含量的影响 |
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| 引用本文： | 谢梅林 顾振纶 陈可冀,周文轩 郭次仪.消淤片对粥样硬化兔血清LDL电泳迁移速度及含TC和TG含量的影响[J].中国药学杂志,2001,36(2):93-95. |
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| 作者姓名： | 谢梅林 顾振纶 陈可冀 周文轩 郭次仪 |
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| 作者单位： | 谢梅林（苏州中药研究所，江苏 苏州 215007）
顾振纶（苏州中药研究所，江苏 苏州 215007）
陈可冀（中国中医研究院西苑医院，北京 100091）
周文轩（香港保健协会，香港）
郭次仪（香港保健协会，香港） |
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| 基金项目： | 香港保健协会资助项目(960086) |
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| 摘 要： | 目的探讨消淤片减少动脉粥样斑块中脂质沉积的作用机制。方法采用高脂饮食加腹主动脉内膜剥脱术制成兔腹主动脉粥样硬化模型，通过一次性密度梯度离心分离血清LDL，测定口服消淤片0.16～0.32g·kg·d-116周后血清LDL电泳迁移速率及含’rc和TG含量的改变。结果 服用消淤片后，兔血清LDL电泳迁移速率减慢，其所含的TC和TG含量减少。结论消淤片不仅有抗LDL氧化作用，而且也能降低LDL中的TC和TC含量，这可能是减少动脉粥样硬化斑块中泡沫细胞及胆固醇积聚的重要机制之一。
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| 关 键 词： | 动脉粥样硬化 氧化型LDL 消淤片 |
| 文章编号： | 1001-2494(2001)02-0093-03 |
| 收稿时间： | 1999-03-22; |
| 修稿时间： | 1999年3月22日 |
Effects of Xiaoyu tablets
on the electrophoretic mobility of serum LDL and levels of total cholesterol and
triglyceride of LDL in atherosclerotic rabbits |
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| XIE Meilin,GU Zhen lun ,CHEN Ke ji,ZHOU Wen xuan,GUO Ci yi.Effects of Xiaoyu tablets
on the electrophoretic mobility of serum LDL and levels of total cholesterol and
triglyceride of LDL in atherosclerotic rabbits[J].Chinese Pharmaceutical Journal,2001,36(2):93-95. |
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| Authors: | XIE Meilin GU Zhen lun CHEN Ke ji ZHOU Wen xuan GUO Ci yi |
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| Institution: | XIE Meilin1,GU Zhen lun 1,CHEN Ke ji2,ZHOU Wen xuan3,GUO Ci yi 3 |
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| Abstract: | OBJECTIVE To investigate the action mechanism of Xiaoyu tablets on reducing the deposition of lipid in atherosclerotic plaque. METHODS The experimental atherosclerotic rabbits were created by feeding high fat diet plus performing abrasion of the abdominal aorta endothelial cells using 4F Forgarty balloon catheter. Serum LDL was isolated by one-step density gradient ultracentrifugation. The changes in electrophoretic mobility of serum LDL and levels of total cholesterol (TC) and triglyceride(TG)of LDL were determined after treated with Xiaoyu tablets 0.16～0.32g·kg-1·d-1 for 16 weeks.RESULTS The electrophoretic mobility of serum LDL was slowed and the levels of TC and TG of LDL were decreased in the treatment groups.CONCLUSION Xiaoyu tablets could prevent the oxidized-LDL formation and lower the levels of TC and TC of LDL.This might be one of its main mechanism of reduction of foam cells and cholesterol in atherosclerotic plaque. |
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| Keywords: | atherosclerosis oxidizedLDL Xiaoyu tablet |
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