| Kanglaite combined Gemcitabine inhibits growth of nude mouse subcutaneous transplantation tumor of human PC-3 pancreatic cancer cell |
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| 作者姓名： | 王伟 金建光 秦兆寅 |
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| 作者单位： | [1]Department of General Surgery, Second Hospital, Xi＇an Jiaotong University, Xi＇an 710004, China [2]Department of General Surgery, First Hospital, Henan Science and Technology University, Luoyang 471003, China |
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| 摘 要： | Objective：To study the mechanisms of pancreatic cancer treatment with Kanglaite combined Gemcitabine by investigating the relationship between the apoptosis and the expression of bcl-2, Bax and VEGF in pancreatic cancer cells. Methods：Nude mouse subcutaneous transplantation tumor model of Human PC-3 pancreatic cancer was established; the expressions of bcl-2, Bax and VEGF of transplantation tumor cell were determined; the earlier apoptosis rate of pancreatic cancer cell and the gross tumor volume were determined. Results ..Kanglaite combined Gemcitabine remarkably decreased the protein expression of bcl-2,raised the expression of Bax,increased the apoptosis rate of the pancreatic cancer and contract the gross tumor volume. Kanglaite greatly decreased the protein expression of VEGF of the tumor cell. Conclusion ：Therapeutic efficacy of Kanglaite combined Gemcitabine is far better than separate use of the two medicines in the pancreatic cancer transplantation tumor treatment.
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| 关 键 词： | 裸鼠 动物实验 皮肤移植 PC-3 胰腺肿瘤 肿瘤细胞 |
| 收稿时间： | 2005-03-26 |
| 修稿时间： | 2005-06-26 |
Kanglaite combined Gemcitabine inhibits growth of nude mouse subcutaneous transplantation tumor of human PC-3 pancreatic cancer cell |
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| Wang Wei;Jin JianGuang;Qin ZhaoYin.Kanglaite combined Gemcitabine inhibits growth of nude mouse subcutaneous transplantation tumor of human PC-3 pancreatic cancer cell[J].Journal of Medical Colleges of PLA(China),2005,20(4):219-222,235. |
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| Authors: | Wang Wei;Jin JianGuang;Qin ZhaoYin |
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| Abstract: | Objective:To study the mechanisms of pancreatic cancer treatment with Kanglaite combined Gemcitabine by investigating the relationship between the apoptosis and the expression of bcl-2, Bax and VEGF in pancreatic cancer cells.Methods:Nude mouse subcutaneous transplantation tumor model of Human PC-3 pancreatic cancer was established; the expressions of bcl-2, Bax and VEGF of transplantation tumor cell were determined; the earlier apoptosis rate of pancreatic cancer cell and the gross tumor volume were determined. Results:Kanglaite combined Gemcitabine remarkably decreased the protein expression of bcl-2,raised the expression of Bax,increased the apoptosis rate of the pancreatic cancer and contract the gross tumor volume. Kanglaite greatly decreased the protein expression of VEGF of the tumor cell. Conclusion:Therapeutic efficacy of Kanglaite combined Gemcitabine is far better than separate use of the two medicines in the pancreatic cancer transplantation tumor treatment. |
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| Keywords: | human PC-3 pancreatic cancer nude mouse subcutaneous transplantation tumor apoptosis immunohistochemisry bcl-2 Bax VEGF |
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