| 肺癌患者淋巴细胞染色体脆性位点表达的研究 |
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| 引用本文： | 蔡绍京,高锦声.肺癌患者淋巴细胞染色体脆性位点表达的研究[J].中国优生与遗传杂志,1996(2). |
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| 作者姓名： | 蔡绍京 高锦声 |
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| 作者单位： | 徐州医学院，苏州医学院 |
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| 摘 要： | 作者检测了３０例肺癌患者和２０例正常对照个体自发和阿糖胞苷诱发的外周血淋巴细胞染色体脆性位点表达率。结果显示：患者组自发和阿糖胞苷诱发的脆性位点表达率显著高于对照组。提示肺癌患者的染色体不稳定性高是其患癌易感性的重要遗传基础。本文还讨论了常见型脆性位点３ｐ１４的高表达率与肺癌的关系，以及肺癌患者的脆性位点与癌断点、癌基因、抗癌基因的相关性等问题。
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| 关 键 词： | 肺肿瘤，染色体脆性位点，癌基因 |
A study of chromosome fragile site in the patients with lung cancer |
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| Cai Shaojing, Gao Jinsheng,.A study of chromosome fragile site in the patients with lung cancer[J].Chinese Journal of Birth Health & Heredity,1996(2). |
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| Authors: | Cai Shaojing Gao Jinsheng |
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| Abstract: | Chromosome fragile site of peripheral lymphocytes were examined in 25 patients with lung cancer and 20 nomal individuals.The resule showed that fragile site expressive frequencies including spontaneous and induced with Ara-C in the patients group were higher than that of the controls. The significance of fragile sites expres sive frequency of the patients group increasing, relationship between high expressive frequency of c-fra 3p 14 and lune cancer and the interrela tionship among chromosome fragile site ,cancer breakpoint, oncogene and anti-oncogene involved in fragile sites were discussed. |
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| Keywords: | Lung neoplasms Chromosome fragile sites Oncogenes |
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