光化学诱导树鼠句血栓性局部脑缺血及其对脑-心卒中的影响

近年来，虽然心脑血管疾病的防治已取得长足的进步，但其仍是全球死亡率最高的疾病之一。脑血栓形成时继发性脑缺血的机制以及脑缺血时心脏功能抑制等诸多复杂的病理生理过程给实验性脑缺血研究时动物种类、模型建立以及观察指标的选择提出了新的要求。本文采用了低等灵长类动物—树鼠句，建立与临床脑缺血发病条件相近的光化学诱导脑缺血模型，在观察不同种类单胺类递质消长变化的同时，通过密度梯度法动态而快速地监测皮层脑水含量的改变，类似的研究迄今未见报道。同时通过此研究为前期工作所观察到“心肌挫抑”（ｓｔｕｎｎｉｎｇ）及线…

Effect of Monoamine Neurotransmitters on Brain Edema and Cerebral-Cardiac Stroke Following Photochemically Induced Thrombotic Cerebral Ischemia in Tree Shrews

Objective: To investigate the relationship between the monoamine neurotransmitters and cerebral cardiac stroke after photochemical reaction. Method: An animal model of photochemically induced thrombotic focal ischemia in tree shrews were produced by radiating the right skull. The measurements of monoamine neurotransmitters in cortex and plasma and of brain water contents were performed. Results: Norpinephrine(NE), dopamine(DA), and serotonine(5 HT) decreased markedly, but 5 hydroxyindole 3 acetic(5 HIAA) acid increased gradually with the ischemic time( P < 0.01 ). The brain water content was higher than that of the control( P < 0.01 ). Moreover, plasma NE increased during 24 hours but decreased at 72 hours after photochemical reaction( P < 0.01 ). Conclusion: The monoamine neurotransmitters could enhance cerebral vascular permeability, promote the formation of brain edema and contribute to the pathogenesis of cerebral carding stroke after cerebral ischemia.