急性心肌梗死后血清GM-CSF水平变化及其与心功能的相关性

目的研究急性心肌梗死（AMI）后患者血清粒细胞-巨噬细胞集落刺激因子（GM-CSF）水平变化,及其与心功能的关系。方法AMI患者30例,AMI后8,16,24,36,48 h及3,4,5,6,7 d分别测定血清GM-CSF,肌酸激酶同工酶（CK-MB）浓度。并在AMI 1周后测量左室射血分数（LVEF）,左室舒张末期内径（LVEDD）。从30例患者中选取5例急性广泛前壁心梗,并且LVEF<40%的患者作为亚组,描述心梗后GM-CSF时间相;并分析30例患者血清GM-CSF峰值与心梗后心功能的关系。结果GM-CSF在AMI后8 h开始逐渐升高,3672 h达高峰,在以后7 d的测量中均保持较高水平。GM-CSF峰值与CK-MB峰值呈正相关（r=0.566,P<0.05）;与LVEF呈负相关（r=-0.42,P<0.05）;与LVEDD呈正相关（r=0.454,P<0.05）。结论心肌梗死后血清GM-CSF水平增高与心功能呈负相关。

Serum profiles of circulating granulocyte-macrophage colony-stimulating factor after acute myocardial infarction and its relation with ventricular function

AIM To investigate the kinetics of granulocyte-macrophage colony-stimulating factor(GM-CSF) in the serum of patients with acute myocardial infarction(AMI) and its relation with post-infarction ventricular function.METHODS Serum levels of GM-CSF and creatine kinase isoenzyme(CK-MB) were determined serially in 30 AMI patients(after AMI 8 h,16 h,24 h,36 h,48 h,3 d,4 d,5 d,6 d,7 d).Left ventricular ejection fraction(LVEF) and left ventricular end-diastolic dimension(LVEDD) were determined one week after AMI.Out...