Methylation analysis of SFRP genes family in cervical adenocarcinoma |
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| Authors: | Lin Ya-Wen Chung Ming-Tzeung Lai Hung-Cheng De Yan Ming Shih Yu-Leung Chang Cheng-Chang Yu Mu-Hsien |
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| Affiliation: | (1) Department of Microbiology and Immunology, National Defense Medical Center, No. 161, Section 6, Min-Chuan East Road, Taipei, 114, Taiwan;(2) Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan;(3) Department of Obstetrics and Gynecology, Army Forces Tao-Yuan General Hospital, Tao-Yuan, Taiwan;(4) Department of Obstetrics and Gynecology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan;(5) Institute of Cancer Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan;(6) Division of Gastroenterology, Department of Internal Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan;(7) Laboratory of Epigenetics, National Defense Medical Center, Taipei, Taiwan |
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| Abstract: | Objectives Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cancers. Recently, we have shown that secreted frizzled-related proteins (SFRPs) are frequently methylated in cervical squamous cell carcinoma (SCC). Furthermore, reexpression of SFRP1 and SFRP2 could suppress tumor cell transformation and invasion. Here, we want to further investigate the methylation status and function of SFRPs in adenocarcinoma of uterine cervix. |
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