飞行员血管紧张素转换酶、血管紧张素原和血管紧张素受体1基因多态性分析

目的：了解飞行员血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性、血管紧张素原（AGT）基因M235T多态性和血管紧张素受体1（ATR1）基因A1166C多态性情况，探讨三种基因多态性与飞行员耐力可能的关系。方法：用聚合酶链反应（PCR）扩增和产物酶切技术检测253例飞行员和236例健康对照者的三种基因多态性。结果：飞行员组ACE Ⅱ基因型（45.06%）和Ⅰ等位基因频率（0.67）显著高于健康对照组（分别为31.36%和0.52），而AGT和ATR1基因多态性在两组间无明显差异。 结论：ACE Ⅰ基因有可能在飞行员的飞行耐力中起重要作用。

A study of gene polymorphism of the angiotensin-converting enzyme, angiotensinogen and angiotensin receptor type 1 in pilots

Objective:To understand gene polymorphism of the angiotensin-converting enzyme,angiotensinogen and angiotensin receptor type 1 in pilots,and to investigate the association between gene polymorphism and the perfomance of the pilots.Methods:253 pilots and 236 healthy control subjects were genotyped for the insertion/delation(I/D) polymorphism of the(angiotensin)-converting enzyme(ACE) gene,M235T polymorphism of angiotensinogen(AGT) gene and A1166C polymorphism of angiotensin receptor type 1(ATR1) gene by the polymerase chain reaction(PCR).Results:It was showed the genotype II and I allele frequency of ACE were significantly higher in pilots(45.06% and 0.67) than that in healthy subjects(31.36% and(0.52)).No difference between the two groups was found for the AGT and ATR1 genotypes.Conclusion:It is suggested that I gene of ACE may play a role in performance of the pilots.peptidyl-dipeptidase A;angiotensinogen;receptors,angiotensin;aviator