槲皮素对在体大鼠心肌缺血再灌性心律失常的保护作用

本文用在体Wistar大鼠心肌缺血再灌注模型,观察槲皮素对缺血再灌性心律失常的保护作用。在再灌前1min至再灌后2min静脉滴注槲皮素(0.5mmol/L,10ml/kg),可显著缩短心律失常的持续时间,降低室颤的发生率、再灌注区心肌组织中MDA的含量及XOD的活性,而对SOD具有明显的保护作用。结果提示槲皮素的抗心肌缺血再灌性心律失常作用可能与抑制心肌组织中OFR的形成和保护心肌组织中SOD或直接清除OFR有关。

Protective effects of quercetin on ischemic reperfusion-induced arrhythmias in the rat heart in vivo

Reperfusion-induced arrhythmias were elicited in the pentobarbitone-anaesthetized rat by the ligation of the left main coronary artery and subsequent release. To observe the protective effects of quercetin on reperfusion-induced arrhythmias, we measured the malondialdehyde (MDA), superoxide dismutase (SOD), and xanthine oxidase (XOD) of myocardial tissues, together with a record of standard lead n ECG. When quercetin (0.5 mmol/L, 10 ml / kg) was administered intravenously 1 min before the ligature released and 2 min after reperfusion, it reduced the incidence of ventricular fibrillation (p<0.05), significantly shortened the duration of reperfusion-induced arrhythmias (p<0.01), effectivelyprotected the activity of SOD (p<0.01), and obviously decreased the activity of XOD (p<0.01) and the content of MDA (p<0.01) in ischemia-reperfusion myocardial tissues. The results suggested that the mechanism of the antiarrhythmic effect of quercetin was associated with the inhibition of the generation of oxygen free radicals, with the prevention of inactivation of SOD and / or with the direct scavenging of oxygen free radicals in the myocardial tissues.