婴儿肝炎综合征临床研究

目的探讨婴儿肝炎综合征病因、临床表现、并发症以及针对病因的相关治疗和疗效。方法对符合婴儿期起病、黄疸、肝脏肿大和肝功能障碍特征的44例病例,进行临床资料的回顾性分析,采用酶联免疫吸附试验法检测血清病毒抗原抗体,进行相关影像学检查及代谢病筛查等。对其中符合TORCH病毒感染的21例予以更昔洛韦进行治疗。结果44例病例中24例(54.5%)明确为感染相关性;44例皆以黄疸不退或退而复现首诊,均有不同程度肝功能损害。给予保肝利胆、利湿退黄、能量支持及祛除病因等治疗,2周为一疗程,通过胆红素、肝酶、肝脏大小等指标进行评价(P<0.001),1～3个疗程显示治疗有效率为86.4%。结论TORCH感染为婴儿肝炎综合征常见病因,黄疸为其首诊表现,常合并多系统损害,综合治疗,效果肯定。

Clinical Analysis of Infantile Hepatitis Syndrome

Objective To analyze the etiology, clinical features, complications and therapy efficacy of infantile hepatitis syndrome. Methods Retrospective analysis of the database was performed on patients present with the onset of infant, jaundice, hepatomegaly and liver function abnormalities. Detect TORCH- IgM and TORCH-IgG by the way of enzyme-linked immunosorbent assay, also adopt imageology and metabolic disease screening methods. 21 cases infected by TORCH were treated with Ganciclovir. Results Of the 44 patients with infantile hepatitis syndrome, 24 of which were identified to be infected by pathogenic micro-organism, the infective rate was 54.5%; All cases came for persistent jaundice or delayed regression, .and suffered Hepatic function damage. 44 cases were offered ordinary therapy, 14 days were set as a course of treatment, indexes for evaluating curative effects such as ALT, TBIL, DBIL and liver size degraded markedly（P〈0.001）. Effective power came to 86.4% alter 1 to 3 courses of treatment. Conclusion TORCH infection is still the chief cause of infant hepatitis syndrome, most cases came for persistent jaundice or delayed regression. IHS usually combines with multisystem damages, with ordinary therapy, therapy efficacy is identified.