miRNA‐Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis |
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| Authors: | Ashish Ranjan Sharma Garima Sharma Sang‐Soo Lee Chiranjib Chakraborty |
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| Affiliation: | 1. Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, Republic of Korea;2. Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India |
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| Abstract: | Rheumatoid arthritis (RA) is an inflammatory disease that primarily affects joints. This autoimmune disease pathogenesis is related to cytokine signaling. In this review, we have described the existence of various microRNAs (miRNAs) involved in regulation of major protein cascades of cytokine signaling associated with RA. Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF‐α, IL‐1, IL‐6, IL‐10, IL‐17, IL‐18, IL‐21, and granulocyte macrophage colony‐stimulating factor (GMCSF). Along with this, we have also discussed the miRNA regulation in T cells and synovial tissue. From the analyzed data, we suggest that miR‐146a and miR‐155 might be the potential therapeutic target for treating RA. The insight illustrated in this review will offer a better understanding of the role of miRNA in cytokine signaling pathways and inflammation during RA and could project them as diagnostic or therapeutic agents in near future. |
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| Keywords: | rheumatoid arthritis cytokine signaling microRNA inflammation autoimmune disease |
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