| AMPK-能量代谢感受器与可激活AMPK相关的药物研究进展 |
| |
| 引用本文： | 耿凤豪,张鹏,董玲,高峰.AMPK-能量代谢感受器与可激活AMPK相关的药物研究进展[J].心功能杂志,2014(1):97-100. |
| |
| 作者姓名： | 耿凤豪 张鹏 董玲 高峰 |
| |
| 作者单位： | [1]第四军医大学基础部生理学教研室,陕西西安710032 [2]兰州军区乌鲁木齐总医院骨科,新疆乌鲁木齐830000 |
| |
| 基金项目： | 国家科技重大专项课题资助（2009ZX09301-009）;陕西省中医管理局中医药科研课题资助（jc38） |
| |
| 摘 要： | 单磷酸腺苷活化蛋白激酶（AMPK）可以感受细胞能量代谢变化，调节细胞的葡萄糖、脂肪酸的代谢过程。AMPK与细胞生长、生存和多种代谢信号途径关系密切，研究发现AMPK信号途径涉及炎症、肿瘤和代谢疾病。本文综述AMPK的功能与炎症、肿瘤、代谢类疾病的关系和诸如水杨酸、二甲双胍等药物激活AMPK的研究进展。
|
| 关 键 词： | 单磷酸腺苷活化蛋白激酶 细胞代谢 炎症 肿瘤 胰岛素抵抗 |
New findings in AMP-activated protein kinase |
| |
| Authors: | GENG Feng-hao ZHANG Peng DONG Ling GAO Feng |
| |
| Institution: | 1. Department of Physiology, Fourth Military Medical University, Xi＇an 710032, Shaanxi, China; 2. Department of Orthopedic Surgery, Urumqi General Hospital, Urumqi 830000, Xinjiang, China) |
| |
| Abstract: | A sensor of cellular energy status, the AMP-activated protein kinase （AMPK） exerts some effects on the modulation of glucose and lipid metabolism, which is highly related with cell viability and survival. AMPK is also activated by drugs such as metformin and salicylate. In addition, studies have shown that AMPK also exerts a wide range of effects on the signaling pathways including inflammation, cancer and metabolic disorders. The article focuses on the new findings of AMPK. |
| |
| Keywords: | AMP-activated protein kinase metabolism inflammation tumor insulin resistance |
| 本文献已被 维普 等数据库收录！ |
