老年冠心病和抑郁对血小板活性的影响

目的:观察老年冠心病和抑郁对血小板活性的影响。方法:根据WHO对缺血性心脏病的命名及诊断标准确定冠心病组及非冠心病组。根据抑郁自评量表(SDS)评分分为抑郁组及非抑郁组。将受试对象最终分为非冠心病非抑郁组(n=87例)、冠心病非抑郁组(n=94例)、非冠心病抑郁组(n=85例)、冠心病抑郁组(n=97例),分别测定血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)。结果:各组与非冠心病非抑郁组相比,PLT、MPV、PDW值均升高,差异均有统计学意义(均P0.01)。冠心病非抑郁组和非冠心病抑郁组相比,PLT、MPV、PDW值升高或降低不明显,两组间PLT、MPV、PDW差异无统计学意义。冠心病非抑郁组与冠心病抑郁组相比PLT值升高或降低不明显,差异无统计学意义,MPV、PDW值均升高,差异有统计学意义。非冠心病抑郁组与冠心病抑郁组相比,PLT值升高或降低不明显差异无统计学意义,MPV、PDW值均升高差异有统计学意义。结论:冠心病与抑郁均可使血小板活性增高,当两病共患时血小板活性增高更显著。

Relationship between depression and change of platelet activity in elderly patients with coronary heart disease

AIM： To observe the effects of coronary activity in elderly patients. METHODS： According heart disease （CHD） and depression on the platelet to WHO diagnostic criteria for coronary heart disease and Zung self-rating depression scale （SDS）, subjects in this study were divided into four groups： nondepressed and non-CHD group （n = 87 ）, CHD non-depressed group （n = 94）, depression without CHD group （ n = 85 ）, and CHD and depression group （ n =97）. Platelet count （ PLT）, mean platelet volume （MPV）, and platelet distribution width （PDW） were detected. RESULTS： There was a significant difference in PLT, MPV and PDW between non-depressed and non-CHD group and the other three groups, and PLT, MPV and PDW values were higher in the other three groups. The increase and decrease in regard to the value of PLT, MPV and PDW are not obvious in the non-depressed CHD group and the depression without CHD group. No significant difference was found in the two groups. A significant difference was found in MPV and PDW but no significant difference was seen in PLT. The rise and fall in regard to the value of PLT is not obvious, but MPV and PDW are higher between CHD non-depressed group with CHD and depression group, and between depression without CHD and CHD and depression group. CONCLUSION： Coronary heart disease and depression both may increase platelet activity, and CHD plus depression may further increase platelet activity.