铜川市H型高血压病患者急性脑梗死的危险因素分析

目的:调查铜川市H型高血压病患者急性脑梗死发生的危险因素。方法:铜川市H型高血压病发生急性脑梗死确诊病例561例,进行1∶1配对进行病例对照研究,获得环境暴露等资料,采用EPI-info(6.04)和SPSS(15.0)统计软件进行单因素和多因素Logistic回归分析,计算各因素的调整比值比(OR)和95%可信限(CI)。结果:单因素分析发现,H型高血压病的561例患者并发高脂血症、糖尿病、高C-反应蛋白血症、短暂性脑缺血发作(TIA)、肥胖、吸烟、酗酒等危险因素与急性脑梗死成正相关,差异有统计学意义(均P0.05)。而马来酸依那普利叶酸片能降低H型高血压病患者患脑梗死的风险。多因素分析结果显示,糖尿病、高C-反应蛋白血症、重度颈动脉狭窄、TIA是H型高血压病发生急性脑梗死的主要危险因素,差异有统计学意义(均P0.05)。结论:铜川市H型高血压病患者急性脑梗死的独立危险因素是高C-反应蛋白血症、糖尿病、重度颈动脉狭窄、TIA,马来酸依那普利叶酸片是其保护因素。

Risk factors of acute cerebral infarction in H type hypertensive patients in Tongchuan City

AIM： To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS ： A 1 ： 1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info （6.04） and SPSS （15） were used for the logistic regression analysis of single and multiple fac- tors, and the adjusted odds ratio of each factor （OR） and 95% confidence limit （CI） were calculated. RESULTS ： Single factor analysis found that hyperlipidemia, ischemic attack （TIA）, obesity, smoking and alcoholism were diabetes, high C-reactive protein, transient related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION： The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors.