血小板源性生长因子与系膜增生性肾炎关系及中医药研究进展

血小板源性生长因子（platelet derivedgrowth factor，PDGF）是一种重要细胞因子，具有强烈的促有丝分裂和细胞趋化作用。PDGF与靶细胞膜上相应受体结合后能启动细胞内多条信号转导通路，形成信号网络，在不同组织细胞中起到重要的作用。该文从PDGF的化学生物学特性及其信号通路、PDGF在系膜细胞中的表达以及诱发系膜增生性肾小球’肾炎的机制、中医药对PDGF表达影响的研究进展等方面加以论述，分析了PDGF在系膜增生性肾小球肾炎中所起的作用及中医药对它的调节作用，指出拮抗PDGF表达可能成为中药治疗系膜增殖性肾小球肾炎的新靶点。

Relationship of Platelet-Derived Growth Factor and Mesangial Proliferative Glomerulonephritis and Research Progress in Traditional Chinese Medicine

Platelet-derived growth factor （ PDCF ） is an important cytokine which has a strong sense of promoting mitosis and cell chemotaxis. PDCF starts the multiple signal transduction pathways in cells and forms a network signal after combining with corresponding receptors on target cell membranes. It plays an important role in different tissue cells. This paper discussed the role of PDCF in mesangial proliferative glomerulonephritis and the regulation of Chinese medicine from the aspects including chemistry biological characteristics and signaling pathways of PDCF, PDCF expression in mesangial cells and the mechanism of inducing mesangial proliferative glomerulonephritis and research progress of effect of Chinese traditional medicine on the expression of PDCF, and pointed out that the pharmaceutical antagonism of PDCF expression may be one of the targets of Chinese medicine.