| 急性分离的大鼠海马及皮层神经元快速失活钾电流特性的比较 |
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| 引用本文： | 高秀萍,祁金顺. 急性分离的大鼠海马及皮层神经元快速失活钾电流特性的比较[J]. 山西医科大学学报, 2007, 38(6): 481-483 |
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| 作者姓名： | 高秀萍 祁金顺 |
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| 作者单位： | 山西医科大学生理学教研室,太原,030001 |
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| 摘 要： | 目的 探讨海马及皮层神经元细胞膜上快速失活钾通道的特性。方法 急性分离大鼠海马及皮层神经元;利用whole-cell膜片钳技术记录IA电流。结果 海马神经元上的IA通道电流幅度较皮层神经元大、潜伏期短。结论 海马神经元与皮层神经元上的IA电流特征存在差别。
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| 关 键 词： | 神经元 whole-cell膜片钳 IA通道电流 |
| 文章编号： | 1007-6611（2007）06-0481-03 |
| 修稿时间： | 2007-01-09 |
Comparison of the characteristics of fast-inactivating K+ channel currents in rat hippocampal neurons with those in cerebral cortical neurons |
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| GAO Xiu-ping,QI Jin-shun. Comparison of the characteristics of fast-inactivating K+ channel currents in rat hippocampal neurons with those in cerebral cortical neurons[J]. Journal of Shanxi Medical University, 2007, 38(6): 481-483 |
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| Authors: | GAO Xiu-ping QI Jin-shun |
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| Affiliation: | Dept of Physiology, Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To study the characteristics of voltage-gated fast-inactivating K channel(IA)in hippocampal neurons and cerebral cortical neurons.MethodsAfter rat hippocampal or cerebral cortical neurons were isolated by pronase E,the IA currents were recorded by whole-cell patch clamp technique.ResultsThe amplitudes of IA currents were larger in hippocampal neurons than in cerebral cortical neurons,while the latent periods were shorter in hippocampal neurons than in cerebral cortical neurons.ConclusionThe characteristics of IA currents are different between hippocampal neurons and cerebral cortical neurons. |
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| Keywords: | neurons whole-cell patch clamp IA currents |
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