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| 主压力数量化在优化对乙酰氨基酚片处方中的应用初探 | |
| 引用本文： | 朱赛杰,裴元英,阮克萍,谢吉,柳晨.主压力数量化在优化对乙酰氨基酚片处方中的应用初探[J].中国医药工业杂志,2007,38(7):502-505. |
| 作者姓名： | 朱赛杰 裴元英 阮克萍 谢吉 柳晨 |
| 作者单位： | 1. 复旦大学药学院药剂学教研室,上海,200032 2. 美国国际特品(ISP)公司,上海,200233 3. 上海九衡医药科技发展有限公司,上海,200020 |
| 摘 要： | 运用RIMEK桌面感应压片系统考察主压力对不同处方对乙酰氨基酚片各项质量指标的影响,筛选粘合剂并优化其用量。结果表明,以2%PVPK29/32为黏合剂的处方最佳,在较宽的主压力范围内片剂硬度合格,脆碎度最小,崩解时间最短,溶出最完全。 |
| 关 键 词： | RIMEK桌面感应压片系统 主压力 对乙酰氨基酚 |
| 文章编号： | 1001-8255（2007）07-0502-04 |
| 修稿时间： | 2007-02-12 |
Preliminary Study on Application of Main Pressure Quantization in the Formulation Optimization of Acetaminophen Tablets |
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| Authors: | ZHU Sai-jie PEI Yuan-ying RUAN Ke-ping XIE Ji LIU Chen |
| Institution: | 1. Dept. of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032; 2. International Specialty Products (ISP |
| Abstract: | Effects of the main pressure controlled by RIMEK tablet compression system on the quality of acetaminophen tablets containing different kinds and amount of adhesive were investigated. The results indicated that acetaminophen tablets prepared within the range of the studied main pressure with 2 % PVP K29/32 as the adhesive was the best one among the prepared products. Tablets prepared with optimized formulation were characteristic of qualified hardness, least friability, shortest disintegration time and most complete dissolution. |
| Keywords: | RIMEK tablet compression system main pressure acetaminophen |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |