| 百日咳杆菌毒素S1亚单位突变体的研究进展 |
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| 引用本文： | 张晓丽,章金勇,邹全明.百日咳杆菌毒素S1亚单位突变体的研究进展[J].中国新药杂志,2007,16(14):1075-1077. |
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| 作者姓名： | 张晓丽 章金勇 邹全明 |
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| 作者单位： | 第三军医大学医学检验系临床微生物及免疫学教研室,暨重庆市生物制药工程技术研究中心,重庆,400038 |
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| 摘 要： | 百日咳杆菌毒素(PT)是目前无细胞百日咳疫苗中的主要保护性成分,其中PT的S1亚单位又是其主要的功能性亚基,具有免疫保护活性和多种毒性。在对多个S1突变体的生物学及免疫学研究后发现,其中的一个S1的双位点突变体(PTX-9K/129G)在保持有良好的免疫原性和免疫保护作用的基础上,大大降低了PT的毒性,有望成为理想的百日咳疫苗候补抗原。
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| 关 键 词： | 百日咳杆菌毒素 S1亚单位 突变体 疫苗 |
| 文章编号： | 1003-3734（2007）14-1075-03 |
| 收稿时间： | 2007-02-10 |
| 修稿时间： | 2007-02-10 |
Advances in studies of pertussis toxin S1 mutants |
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| ZHANG Xiao-li,ZHANG Jin-yong,ZOU Quan-ming.Advances in studies of pertussis toxin S1 mutants[J].Chinese Journal of New Drugs,2007,16(14):1075-1077. |
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| Authors: | ZHANG Xiao-li ZHANG Jin-yong ZOU Quan-ming |
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| Institution: | Department of Clinical Microbiology and Immunology, The Third Military University, Chongqing Engineering Technology Research Center of Biopharmaceuticals, Chongqing 400038, China |
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| Abstract: | Pertussis toxin(PT)is a key component of acellular pertussis vaccine.The toxin with the S1 subunit as the toxin subunit is immunodominant.Several genetically detoxified analogues of pertussis holotoxin have been expressed.The most promised toxoid for vaccine purposes(PTX-9K/129G) contains a double mutation in the S1 subunit where Arg-9 is replaced with Lys and Glu-129 is replaced with Gly.It is nontoxin and immunogenic and while remaining the protective epitopes.Therefore,the S1 mutant(PTX-9K/129G) would serve as important target in developing a new-paradigm therapy against pertussis. |
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| Keywords: | Bordetella pertussis toxin S1 subunit mutants vaccine |
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