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| 普鲁卡因和利多卡因对离体兔股动脉的解痉作用 | |
| 引用本文： | 贡沁燕,徐端正,袁伟. 普鲁卡因和利多卡因对离体兔股动脉的解痉作用[J]. 复旦学报(医学版), 1987, 0(4) |
| 作者姓名： | 贡沁燕 徐端正 袁伟 |
| 作者单位： | 上海医科大学基础医学部药理学教研室(贡沁燕，徐端正)，华山医院显微外科研究室(袁伟) |
| 摘 要： | 在离体兔股动脉,利多卡因和普鲁卡因均可使去甲肾上腺素(NA)浓度-效应曲线右移,两药在浓度为1mmol/L时,NA的等效浓度分别是对照的5.6和2.9倍;在3mmol/L时,为70.5和14.6倍。从NA浓度-效应曲线观察到利多卡因对抗NA所致的血管收缩作用更明显。对于预先用NA引起的血管收缩,利多卡因及普鲁卡因均可使之舒张,其IC_(50)分别为1.3与2.1 mmol/L。两药合用,用等效线提示为相加作用。 |
| 关 键 词： | 兔股动脉 去甲肾上腺素 普鲁卡因 利多卡因 浓度-效应曲线 等效浓度比 IC_(60) |
THE ANTISPASMODIC ACTION OF LIDOCAINE AND PROCAINE IN ISOLATED RABBIT FEMORAL ARTERY |
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| Gong Qinyan,Xu Duanzheng,Yuan Wei. THE ANTISPASMODIC ACTION OF LIDOCAINE AND PROCAINE IN ISOLATED RABBIT FEMORAL ARTERY[J]. Fudan University Journal of Medical Sciences, 1987, 0(4) | |
| Authors: | Gong Qinyan Xu Duanzheng Yuan Wei |
| Abstract: | 1mmol, L and 3mmol/L of lidocaino or procaine caused a right shift In the concentraation-effect curve of noradrenalino(NA) , The equi-effect concentration ratio of MA was 5,6-fold and 2.9-fold of the control in the presence of 1mmol/L of lido-caine or procaino; and 70.5-fold and 14,6-fold of the control in the presence- of 3mmol/L lidocaine or procaine. The concentration effect curve of NA was depressed by 1mmol/L or 3mmol/L of lidocaine, but not by procaltio. The intensify of NA (0,01 mmol/L) induced contraction of isolated rabbit femoral artery could be reduced by lidocaine and procaine. The potency of the former was higher than that of the latter. IC50 being 1.3mmol/L and 2.1nimol/L respectively. The antispasmodio effect on the arterial smooth muscle by lidocaine and procaine mixture was found to be additive. |
| Keywords: | rabbit femoral artery noradrenaline procaine lidocaine concentra-tion-effect ourve equi-effect concentration ratio IC:50 |
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