Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats |
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| Authors: | Else Marie Pinholt Eirik Solheim Gisle Bang Einar Sudmann |
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| Affiliation: | a Institute for Surgical Research, Rikshospitalet, University of Oslo, Norwayb Department of Oral Pathology, Forensic Odontology, Norwayc Hagavik Orthopedic Hospital, University of Bergen, Norway |
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| Abstract: | A composite of a local, sustained, drug-release system, Alzamer® bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by 85Sr uptake. the composite implant was technically easier to use than DBM alone. |
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