青少年支气管哮喘与气道反应性的遗传流行病学分析

利用遗传流行病学的方法，调查了230个子女为青少年（6－16岁）的哮喘核心家系，分析了父或母对子女患哮喘和气道高反应性的影响。结果显示：在哮喘核心家系中，儿子比女儿更易患哮回与气道高反应性；与父母均无哮喘史家系的子女比较，父母亲的哮喘史将使子女患哮喘的危险性增加10-30倍（P＜0．01），其中母亲对子女的影响更为明显，是父亲对子女影响的两倍。父母的气道高反应性也显著增加子女气道高反应性的危险性（OR=2.49，P＜0．01）。不仅遗传因素是支气管哮喘的重要危险因素之一，而且气道高反应性与遗传因素密切相关。两者可能既有共同的遗传基础又有各自不同的遗传易感基因。

A Genetic Epidemiological Study on Asthma and Airway Responsiveness

With the method of genetic epidemiology 230 astma nuclear families were investigated and dataon asthma and airway responsiveness were analysed . Compared with offsprings whose parents had no asthmahistory, those whose parents had the history were 10 to 30 times as likely to suffer from the disease. In asthmanuclear families , more sons than daughters suffered from the disease, The effect of mothers asthma history weretwice as great than fathers on their offsprings suffering from the disease . A significant association was foundbetween parents and their offsprings in hyperresponsiveness (OR = 2.49, P <0. 01). The results suggest thatgenetic factors are important risk factors for asthma, and hyperresponsiveness is related to genetic factors