| 慢性乙型病毒性肝炎中Bcl-2及Bax的表达与T、B淋巴细胞数量变化的关系 |
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| 引用本文： | 郭芳,陈秋月,周英琼,林静,李美琼,侯巧燕.慢性乙型病毒性肝炎中Bcl-2及Bax的表达与T、B淋巴细胞数量变化的关系[J].现代医药卫生,2011,27(20):3047-3049. |
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| 作者姓名： | 郭芳 陈秋月 周英琼 林静 李美琼 侯巧燕 |
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| 作者单位： | 桂林医学院附院病理科病理教研室,广西桂林,541001 |
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| 基金项目： | 广西教育科学“十一五”规划B类课题(课题编号:2008B36); 广西卫生厅自筹经费课题(合同号:Z2010314) |
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| 摘 要： | 目的:研究Bcl-2及Bax在慢性乙型病毒性肝炎(简称慢乙肝)患者肝组织中淋巴细胞的表达与T、B淋巴细胞数量变化的关系.方法:用免疫组织化学的方法,检测57例慢乙肝患者肝脏活检组织和20例肝血管瘤患者外科手术切除标本正常肝组织淋巴细胞中Bcl-2,Bax的分布及数量的变化,并同时进行CD3和CD20免疫组织化学染色,计算T和B淋巴细胞数量变化与表达Bcl-2、Bax的淋巴细胞数量变化的关系.阳性细胞的计数和分析数据均使用病理图像分析仪获得.结果:随着肝炎炎症活动度和纤维化程度的增加,慢乙肝患者肝组织中表达Bcl-2、Bax的淋巴细胞数量增加,同时T、B淋巴细胞数量也增多,均明显多于正常肝组织(P＜0.01).结论:Bcl-2、Bax在慢乙肝患者肝组织淋巴细胞中的表达与T、B淋巴细胞数量的变化有关,并影响慢乙肝患者炎症活动度和纤维化程度的进展.
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| 关 键 词： | 慢性乙型病毒性肝炎 细胞调亡 Bcl-2 Bax T淋巴细胞 B淋巴细胞 |
Bcl-2 and Bax expression and its relation with number of T and B lymphocytes in patients with chronic hepatitis B |
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| GUO Fang
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CHEN Qiu-yue
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ZHOU Ying-qiong
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LIN Jing
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LI Mei-qiong
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HOU Qiao-yan.Bcl-2 and Bax expression and its relation with number of T and B lymphocytes in patients with chronic hepatitis B[J].Modern Medicine Health,2011,27(20):3047-3049. |
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| Authors: | GUO Fang CHEN Qiu-yue ZHOU Ying-qiong LIN Jing LI Mei-qiong HOU Qiao-yan |
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| Institution: | GUO Fang,CHEN Qiu-yue,ZHOU Ying-qiong,LIN Jing,LI Mei-qiong,HOU Qiao-yan(Department of Pathology,Affiliated Hospital,Guilin Medical College,Guilin,Guangxi 541001,China) |
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| Abstract: | Objective:To investigate Bcl-2 and Bax expression and its relation with the number of T and B lymphocytes in the patients with chronic hepatitis B.Methods:By using immunohistochemical technology,Bcl-2 and Bax positive cells were detected in 57 liver-aspiration-biopsy-specimens from chronic HBV infective patients and 20 normal liver-surgical-specimens from hepatic haemangioma patients.At the same time,CD3 and CD20 immunohistochemical staining was performed,the number of T and B lymphocytes was calculated and... |
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| Keywords: | Chronic hepatitis B apoptosis bcl-2 Bax T lymphocyte B lymphocyte |
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