A型肉毒毒素注射治疗对痉挛型脑瘫患儿运动功能及健康相关生活质量的影响

目的:探讨下肢A型肉毒毒素(botulinum toxin type A,BTX-A)注射治疗对痉挛型双瘫患儿躯体运动功能和健康相关生活质量的影响.方法:51例2岁1个月～9岁6个月痉挛型双瘫患儿随机分为BTX-A注射组26例和对照组25例.患儿均给予系统性康复治疗6个月,注射组在入组第一天给予1次BTX-A注射治疗.在治疗前,治疗后1个月、3个月、6个月对患儿运动功能和生活质量进行评估.结果:注射组与对照组相比用改良Ashworth量表(Modified Ashworth Scale,MAS)量化评分组间差异有统计学意义(P＜0.05)；注射组与对照组相比粗大运动功能评分(Gross Motor Function Measure,GMFM)走跑跳功能评分组间差异有统计学意义(P＜0.05)；儿科生活质量调查表(The Pediatric Quality of Life Inventory Measurement Models,PedsQL)生理领域的时间因素以及时间因素和分组的交互作用比较有统计学意义(P＜0.05),注射组提高趋势更明显,而心理领域差异无统计学意义(P＞0.05).结论:A型肉毒毒素辅助治疗能更有效改善脑瘫患儿的肌肉痉挛和运动功能,但是短时间内对其社会、心理、情感等方面的功能无明显改善作用.

Effect of botulinum toxin-A therapy on motor function and health-related quality of life in children with spastic cerebral palsy

Objective:To investigate the effect of lower limb botulinum toxin-A(BTX-A) therapy on motor function and health-related quality of life in children with diplegic spastic cerebral palsy(CP).Methods:51 spastic cerebral palsy children aged 2 years 1 month-9 years 6 months were randomly divided into BTX-A treatment(26 cases) and control groups(25 cases),respectively.All cases were given systematic rehabilitation therapy for 6 months.The treatment group was injected with BTX-A at baseline.The motor function and ...